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This book is one of a series of distance learning books for healthcare professionals in under-resourced areas. The aim of the book is to enable healthcare workers at primary care clinics to manage all aspects of HIV-related patient care. It includes an introduction to HIV infection, management of HIV-infected adults at primary care clinics, preparing patients for antiretroviral treatment, antiretroviral drugs, starting and maintaining patients on antiretroviral treatment, and an approach to opportunistic infections.